ABSTRACT
Some infectious diseases such as COVID-19 have the characteristics of long incubation period, high infectivity during the incubation period, and carriers with mild or no symptoms which are more likely to cause negligence. Global researchers are working to find out more about the transmission of infectious diseases. Modeling plays a crucial role in understanding the transmission of the new virus and helps show the evolution of the epidemic in stages. In this paper, we propose a new general transmission model of infectious diseases based on the generalized stochastic Petri net (GSPN). First, we qualitatively analyze the transmission mode of each stage of infectious diseases such as COVID-19 and explain the factors that affect the spread of the epidemic. Second, the GSPN model is built to simulate the evolution of the epidemic. Based on this model’s isomorphic Markov chain, the equilibrium state of the system and its changing laws under different influencing factors are analyzed. Our paper demonstrates that the proposed GSPN model is a compelling tool for representing and analyzing the transmission of infectious diseases from system-level understanding, and thus contributes to providing decision support for effective surveillance and response to epidemic development.
ABSTRACT
The coronavirus disease 2019 (COVID-19) has become a global pandemic since its outbreak in December 2019, which posed a threat to the safety and well-being of people on a global scale. Cancer patients are at high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and their critical morbidity and case fatality rates are high. The ablation expert committee of the Chinese Society of Clinical Oncology compiled corresponding expert recommendations. These recommendations summarize the preventive measures and management of tumor ablation treatment in medical institutions, including outpatient clinics, oncology wards, ablation operation room, and postablation follow-ups in accordance with the guidelines and protocols imposed by the National Health Commission of the People's Republic of China and the experience in management and prevention according to various hospitals. This consensus aims to reduce and prevent the spread of SARS-CoV-2 and its cross-infection between cancer patients in hospitals and provide regulatory advice and guidelines for medical personnel.